MODULATING GENE EXPRESSION WITH AGRNA AND GAPMERS TARGETING ANTISENSE TRANSCRIPTS
摘要
Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream relative to the transcription start site of the gene; and detecting a resultant modulation of expression of the target gene.
申请公布号
WO2009046397(A2)
申请公布日期
2009.04.09
申请号
WO2008US78881
申请日期
2008.10.04
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;SCHWARTZ, JACOB, C.;YOUNGER, SCOTT, T.;JANOWSKI, BETHANY, A.;COREY, DAVID, R.
发明人
SCHWARTZ, JACOB, C.;YOUNGER, SCOTT, T.;JANOWSKI, BETHANY, A.;COREY, DAVID, R.