发明名称 |
Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides |
摘要 |
The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides. |
申请公布号 |
AU2008307510(A1) |
申请公布日期 |
2009.04.09 |
申请号 |
AU20080307510 |
申请日期 |
2008.10.03 |
申请人 |
ONYX THERAPEUTICS, INC. |
发明人 |
GUY J. LAIDIG;PASIT PHIASIVONGSA;WILLIAM DEAN FULLER;LOUIS C. SEHL |
分类号 |
C07K5/10;A61P19/08;A61P25/28;A61P31/00;A61P33/00;A61P35/00;A61P37/00;A61P37/06;C07D303/36;C07K5/107 |
主分类号 |
C07K5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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