INTERLEUKIN-9 AND INTERLEUKIN-4 CHIMERIC ANTAGONIST MUTEINS AND METHODS OF USING SAME
摘要
Chimeric polypeptide antagonists that include an interleukin-4 (IL-4) mutein linked to an interleukin-9 (IL-9) mutein are provided, as are polynucleotides encoding the IL-4 and IL9 chimeric mutein antagonists. Also provided are methods of using the chimeric mutein antagonists and encoding polypeptides to reduce or inhibit the responsiveness of a cell to a cytokine such as IL-4, IL-9 and/or interleukin-13. Methods using the compositions to treat disorders such as pulmonary disorders (e.g., asthma) also are provided.
申请公布号
WO2006036878(A3)
申请公布日期
2009.04.09
申请号
WO2005US34388
申请日期
2005.09.21
申请人
AEROVANCE, INC.;BOISVERT, DAVID, C.;LONGPHRE, MALINDA;WONG, TERESA, M.;ZAREMBA, SYDNEY, M.
发明人
BOISVERT, DAVID, C.;LONGPHRE, MALINDA;WONG, TERESA, M.;ZAREMBA, SYDNEY, M.