The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.
申请公布号
WO2006086242(A3)
申请公布日期
2009.04.09
申请号
WO2006US03926
申请日期
2006.02.06
申请人
GENENEWS, INC.;LEIW, CHOONG-CHIN;ZHANG, HONGWEI;DEMPSEY, ADAM;YAGER, THOMAS;CHAO, SAMUEL
发明人
LEIW, CHOONG-CHIN;ZHANG, HONGWEI;DEMPSEY, ADAM;YAGER, THOMAS;CHAO, SAMUEL