发明名称 |
COMPOSITIONS AND METHODS FOR TREATING NEURAL ANOXIA AND SPREADING DEPRESSION |
摘要 |
<p>Compositions and methods for protecting neural tissue (e.g., neurons) from anoxia and spreading depression (SD) involve inhibiting the cGMP-dependent protein kinase (PKG) pathway. It was discovered that the PKG pathway plays a crucial role in regulating SD and tolerance to anoxia in the central nervous system (CNS). Inhibition of the PKG pathway greatly reduces SD and increases tolerance to anoxia (i.e., hypoxia), while activation of the pathway exacerbates SD pathology. The compositions and methods can be used to treat any condition associated with SD or anoxia, including stroke, spinal cord injury, neurogenerative disease, dizziness, headaches, and migraines.</p> |
申请公布号 |
WO2009046322(A2) |
申请公布日期 |
2009.04.09 |
申请号 |
WO2008US78785 |
申请日期 |
2008.10.03 |
申请人 |
FLORIDA ATLANTIC UNIVERSITY;DAWSON-SCULLY, KEN;ROBERTSON, R., MELDRUM;ARMSTRONG, GARY, A.B.;SOKOLOWSKI, MARLA |
发明人 |
DAWSON-SCULLY, KEN;ROBERTSON, R., MELDRUM;ARMSTRONG, GARY, A.B.;SOKOLOWSKI, MARLA |
分类号 |
A61K38/08;A61K31/351;A61K31/4985;A61K31/519 |
主分类号 |
A61K38/08 |
代理机构 |
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