发明名称 |
Method for Identifying Within a Mammal a DNA encoding a Physiologically Active Polypeptide |
摘要 |
The present inventors found that a physiological effect of a particular DNA can be detected independently within mice into which a pool of various DNAs in various quantities has been introduced. This finding suggests that it is possible to identify a DNA having a particular physiological effect by successively fractionating a pool of various DNAs in various quantities using the particular physiological effect seen within a mammal as an index. Such a method of screening will have the advantage of saving much time and effort as required in conventional screenings such as those utilizing transgenic and knockout mice. Furthermore, the method of screening has the additional advantage of enabling the identification of a DNA having a physiological activity, for example, even when the cells producing a physiologically active substance cannot be maintained in vitro or in immunodeficient animals, or when the cells change their characteristics during passage and stop producing the physiologically active substance.
|
申请公布号 |
US2009092995(A1) |
申请公布日期 |
2009.04.09 |
申请号 |
US20080327770 |
申请日期 |
2008.12.03 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
HABU KIYOSHI;JISHAGE KOU-ICHI;SUZUKI HIROSHI |
分类号 |
C12Q1/68;A01K67/027;A61K38/00;A61K48/00;A61P3/12;C12N15/10;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|