The present invention provides a method of determining the susceptibility of a dog to liver copper accumulation comprising detecting the presence or absence of (a) a polymorphism in the GOLGA5, ATP7a or UBL5 gene of the dog that is indicative of susceptibility to copper accumulation and/or (b) a polymorphism in linkage disequilibrium with a said polymorphism (a), and thereby determining the susceptibility of the dog to liver copper accumulation. The invention also provides a foodstuff comprising copper at a concentration of less than 21 mg/kg dry matter for use in preventing a disease attributable to liver copper accumulation in a dog having genetic inheritance of the Labrador Retriever breed.
申请公布号
WO2009044152(A2)
申请公布日期
2009.04.09
申请号
WO2008GB03351
申请日期
2008.10.03
申请人
MARS, INCORPORATED;JONES, PAUL, GLYN;MARTIN, ALAN, JAMES;HOFFMANN, GABY;ROTHUIZEN, JAN
发明人
JONES, PAUL, GLYN;MARTIN, ALAN, JAMES;HOFFMANN, GABY;ROTHUIZEN, JAN