SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF HIF1ALPHA

摘要

The present invention relates to oligomer compounds (oligomers) of 12, 13 or 14 nucleotides in length, which target Hif1 alpha mRNA in a cell, leading to reduced expression of Hif1 alpha. Reduction of Hif 1 alpha expression is beneficial for the treatment of certain medical disorders, such as hyperproliferative disorders, such as cancer.