| 摘要 |
A peptide inhibitor of glycogen synthase kinase-3 (GSK-3) comprising a peptide having between 6 and 50 amino acid residues and an amino acid sequence selected from PYYVNSGYA (SEQ ID No: 7), EPVNPYYVNSGYALAP (SEQ ID No: 6), and REPVNPYYVNSGYALAPATS (SEQ ID No: 5). A peptide inhibitor of GSK-3 comprising a peptide having between 13 and 50 amino acid residues and an amino acid sequence represented by the formula: EPXAZ1XBZ2XC(A/S)P (SEQ ID Nos: 54-61 ), wherein XA represents 2 or 3 amino acid residues which can, independently, be any amino acid residue, wherein XB represents 4 or preferably 5 amino acid residues which can, independently, be any amino acid residue, wherein Xc represents 1 or 2 amino acid residues which can, independently, be any amino acid residue, wherein Z1 and Z2, independently, represent Y, S or F and wherein (A/S) represents either A or S. The peptide is not phosphorylated at a tyrosine residue indicated by Y. |
