ANTIBODIES TO HTRA1 AND METHODS OF USING THE SAME

摘要

Antibodies to HtrA1 and methods of using such antibodies are described herein. The antibodies described herein are raised against HtrA1 and variants of HtrA1 as defined herein. The antibodies disclosed herein are useful in treating disease or injury of the eye. For example, in one embodiment, HtrA1 antibodies may be used to treat age-related macular degeneration (AMD) in both its wet and dry forms, diabetic retinopathy (DR), retinopathy of prematurity (ROP) or macular edema. In another embodiment, HtrA1 antibodies may be used to treat choroidal or retinal neovascularization associated with or resulting from disease or injury. In another embodiment, the methods of the present invention include use of HtrA1 antibodies to treat ischemia-induced retinal neovascularization resulting from vascular damage, occlusion or leak resulting from disease or injury. The methods described herein include administering a therapeutically-effective amount of one or more HtrA1 antibodies to a subject. Pharmaceutical compositions of antibodies to HtrA1 are also described herein.