N-TERMINAL CONJUGATION OF POLYSIALIC ACID TO PROTEINS

摘要

A composition comprises a population of polysaccharide derivatives of a protein, wherein the protein is insulin or an insulin-like protein and the polysaccharide is anionic and comprises between 2 and 125 saccharide units, and wherein the population consists substantially only of derivatives of the protein derivatised at the N-terminal of the B-chain.