FLAGELLIN MUTANT VACCINE

摘要

The present invention provides a vaccine which effectively induces protective immune response particularly against flagellated pathogens (such as Pseudomonas aeruginasa). A flagellin mutant into which a mutation has been introduced at least at one site in the Toll-like receptor 5 activation domain of a corresponding wild-type flagellin to thereby attenuate the ability to activate Toll-like receptor 5. A vaccine targeting the flagellin mutant.