摘要 |
<p>Compounds represented by the Formula I or salts, hydrates thereof, wherein R 1 , R 8 , R 11 and R 12 are H or C 1-4 hydrocarbonyl respectively; R 2 , R 3 , R 6 and R 7 are H, halogen or C 1-4 hydrocarbonyl respectively; R 4 is C 1-6 hydrocarbonyl or Ar; or =CR 4 R 3 is cyclopentylidene, cyclohexylidene, 1-methylpiperidyl-4-idene or indenyl-1-idene; R 5 is H, 1-4 same or different F, Cl, Br, CF 3 , R 9 , OR 9 , NR 9 R 10 , NO 2 , CN, COOR 9 , O 2 CR 9 , CONR 9 R 10 , NR 9 C(O)R 10 , heterocyclic, aryl or groups represented by the Formula II respectively; R 9 and R 10 are H or C 1-6 hydrocarbonyl; Ar is aromatic ring; m is 0, 1 or 2; n is 0, 1, 2, 3 or 4, for treating mammal pain, functional painful syndrome, organic painful syndrome or tissue painful syndrome, and their preparation method.</p> |