TREATMENT OF MAMMALIAN DISORDERS MEDIATED BY ALPHA-CARBONIC ANHYDRASE ISOFORMS

摘要

The present invention pertains to 4-(4-methyl?iperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin- 3-yl)pyrimidin-2-ylamino)phenyl]-benzamide or a pharmaceutically acceptable salt thereof, or 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino}-?/-[5-(4--methyl-1H-imidazol-1-yl)-3-(trifluoro- methy!)phenyl] benzamide or a pharmaceutically acceptable salt thereof, for the treatment of disorders mediated by alpha-carbonic anhydrase isoforms selected from intraocular hypertension (glaucoma), epilepsy, Lennox-Gastaut syndrome, altitude sickness, headaches, neurological disorders and obesity.