| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a substituted biphenyl carboxylic acid derivative which functions as a partial agonist or an antagonist of PPARδ. <P>SOLUTION: This substituted biphenyl carboxylic acid derivative is a partial agonist and/or an antagonist selective to PPARδrepresented by formula (1), [wherein R<SB>1</SB>represents a linear, branched or cyclic 1-10C hydrocarbon group or methoxyethoxy group, R<SB>2</SB>represents a hydrogen atom or a halogen atom, R<SB>3</SB>represents a linear, branched or cyclic 1-10C hydrocarbon group, trifluoromethyl group, a phenyl group which may be unsubstituted or substituted, a phenoxy group which may be unsubstituted or substituted or an adamantyl group which may be unsubstituted or substituted, R<SB>4</SB>represents a hydrogen atom, a halogen atom or a 1-10C hydrocarbon group, and X represents CH<SB>2</SB>NHCO group or CONHCH<SB>2</SB>group]. <P>COPYRIGHT: (C)2011,JPO&INPIT</p> |
