发明名称 |
FUCOSYLATION-DEFICIENT CELLS |
摘要 |
An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 21 1, a serine at position 289, and a combination thereof is provided. Cells having a gene encoding a modified FX protein are provided, wherein the cells exhibit a reduced ability to fucosylate a glycoprotein at a first temperature, but exhibit the ability to fucosylate the glycoprotein at a second temperature. Methods and compositions for making glycoproteins with reduced fucosylation are provided. |
申请公布号 |
WO2010141478(A1) |
申请公布日期 |
2010.12.09 |
申请号 |
WO2010US36914 |
申请日期 |
2010.06.01 |
申请人 |
REGENERON PHARMACEUTICALS, INC.;CHEN, GANG;BURAKOV, DARYA;FANDL, JAMES, P. |
发明人 |
CHEN, GANG;BURAKOV, DARYA;FANDL, JAMES, P. |
分类号 |
C12N15/53;C07K16/00;C12N5/10;C12N9/04;C12P21/00 |
主分类号 |
C12N15/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|