Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
申请公布号
CA2952805(A1)
申请公布日期
2010.12.09
申请号
CA20102952805
申请日期
2010.06.04
申请人
CELLULAR DYNAMICS INTERNATIONAL, INC.
发明人
BROWN, MATTHEW;DOMINGUEZ, ELIZABETH RONDON;LEARISH, RANDY;NUWAYSIR, EMILE;RAJESH, DEEPIKA;MACK, AMANDA