MASS SPECTROMETRY USING LASERSPRAY IONIZATION

摘要

Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-based or solvent- free. Solvent-free analysis following LSI allows for improved spatial resolution beneficial in surface and/or tissue imaging.