发明名称 |
Solid pharmaceutical dosage form comprising an HIV protease inhibitor solid dispersion |
摘要 |
A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50 °C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10. |
申请公布号 |
EP2258345(A2) |
申请公布日期 |
2010.12.08 |
申请号 |
EP20100181264 |
申请日期 |
2004.08.23 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
ROSENBERG, JOERG;REINHOLD, ULRICH;LIEPOLD, BERND;BERNDL, GUNTHER;BREITENBACH, JOERG;ALANI, LAMAN;GHOSH, SOUMOJEET |
分类号 |
A61K9/14;A61K9/20;A61K9/28;A61K31/425 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|