发明名称 |
Process for preparing enriched enantiomers of 3-(Benzo[1,3]dioxol-5-yl)-2-methylpropanal |
摘要 |
<p>A process is described for preparing enriched enantiomers of the compound 3-(benzo[1,3]dioxol-5-yl)-2-methylpropanal of formula (I) comprising the following steps: i) reacting the racemic compound 3-(benzo[1,3]dioxol-5-yl)-2-methylpropanol (2) with phthalic anhydride to give the racemic acid (3); ii) resolving the racemic acid (3) with optically active 1-aryl-1-ethanamine (4) in which Ar is an aromatic or heteroaromatic group having from 6 to 12 members optionally substituted with one or more substituents chosen from the group consisting of (C 1 -C 3 ) alkyl, (C 1 -C 3 ) alkoxy and halogen; iii) recovering the (S)-(2) and (R)-(2) alcohols from the resolved acids (3) of step ii) by alkaline hydrolysis; iv) converting the (S)-2 and (R)-2 alcohols into the respective (S) and (R) enantiomers of compound (I).</p> |
申请公布号 |
EP2258696(A1) |
申请公布日期 |
2010.12.08 |
申请号 |
EP20090425187 |
申请日期 |
2009.05.14 |
申请人 |
ENDURA S.P.A. |
发明人 |
BORZATTA, VALERIO;ROSINI, GOFFREDO;RIGHI, PAOLO |
分类号 |
C07D317/54;C11D3/50 |
主分类号 |
C07D317/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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