Pharmaceutical composition, composition for screening therapeutics preventing and treating beta amyloid accumulation in brain comprising GCP II (glutamate carboxypeptidase II) as an active ingredient and method for screening using the same

摘要

The present invention relates to a pharmaceutical composition for the prevention and treatment for &bgr;-amyloid (A&bgr;) accumulation in brain comprising GCP-II (Glutamate carboxypeptidase-II) as an active ingredient, a composition for screening method of the same. GCP-II of the present invention not only degrades A&bgr; monomer and oligomer but also degrades soluble A&bgr; and insoluble A&bgr;, particularly aggregated A&bgr;, so that it can prevent the accumulation of A&bgr; in brain or reduce the accumulation, making it an excellent candidate for the therapeutic agent for Alzheimer's disease and Down's syndrome.