发明名称 |
Apoptosis modulator BCL-B and methods for making and using same |
摘要 |
A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human tissues. The Bcl-B protein modulates apoptosis. Bcl-B also binds Bcl-2. BCl-XL, and Bax but not Bak. Bcl-B displays a unique pattern of selectivity for binding and regulating the function of other members of the Bcl-2 family. Accordingly, provided herein is a method for identifying a molecule that binds to the Bcl-B polypeptide, by contacting the Bcl-B polypeptide with a test molecule and determining whether the test molecule binds to the polypeptide.
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申请公布号 |
US7846681(B2) |
申请公布日期 |
2010.12.07 |
申请号 |
US20090426479 |
申请日期 |
2009.04.20 |
申请人 |
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE |
发明人 |
REED JOHN C.;KE NING;GODZIK ADAM |
分类号 |
G01N33/53;C07K14/47;C12N15/82 |
主分类号 |
G01N33/53 |
代理机构 |
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地址 |
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