发明名称 METHOD FOR THE IDENTIFICATION OF EPITOPES RELATED TO IMMUNOGENICITY IN BIOPHARMACEUTICALS
摘要 The present invention relates to a method for identifying peptides involved in immunogenicity comprising the steps of a) providing cells expressing antigen presenting receptors (APR) in a number providing 0.1 to 5 µg molecules, b) contacting the cells from (a) with a source of immunogenic peptides, c) isolating APR molecule-immunogenic peptide complexes from the cells, d) eluting the associated peptides from the APR molecules, e) identifying the immunogenic peptides, f) verifying the identified immunogenic peptides as epitopes.
申请公布号 CA2542104(C) 申请公布日期 2010.12.07
申请号 CA20062542104 申请日期 2006.04.18
申请人 F. HOFFMANN-LA ROCHE AG 发明人 KROPSHOFER, HARALD;VOGT, ANNE
分类号 C12Q1/02;A61K38/00;G01N33/566;G01N33/567 主分类号 C12Q1/02
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