发明名称 |
POLYPEPTIDES DERIVED FROM AMYLOID PRECURSOR PEPTIDE (APP) AND THEIR USES |
摘要 |
<p>The invention provides a compound having formula
in which X 1 and X 2 are up to 30 amino acid residues and Xaa is an amino acid residue. A preferred compound is the tripeptide Arg-Glu-Arg which corresponds to amino acid residues 328 to 330 of human amyloid precursor protein. The invention further provides a derivative of a polypeptide having the formula:
wherein X 1 and X 2 , which may be the same or different, each represents from zero to 30 natural or synthetic amino acid residues or derivatives thereof and Xaa represents a natural or synthetic amino acid residue or a derivative thereof, at least one functional group of at least one said amino acid residue or derivative thereof being protected by a protective group. The compounds of the invention are believed to be useful in the treatment of Alzheimer's disease and as cognitive enhancers.</p> |
申请公布号 |
EP1381627(B1) |
申请公布日期 |
2010.11.10 |
申请号 |
EP20020720228 |
申请日期 |
2002.04.17 |
申请人 |
THE OPEN UNIVERSITY |
发明人 |
MILEUSNIC, RADMILA;ROSE, STEVEN PETER RUSSELL |
分类号 |
C07K14/47;A61K38/00;A61K38/17;A61P25/28;C07K5/083;C07K5/09;C07K5/103;C07K5/11;C07K7/06 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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