| 摘要 |
Isolated nucleic acids (I) for hepatitis D virus (HDV) are new. Isolated nucleic acids (I) for hepatitis D virus (HDV) comprising: (i) the genome of a HDV that, at the molecular level over the entire genome, has a divergence or genetic distance of at least 20% with respect to HDV of genotypes I-III; (ii) the genome of a HDV that, at the molecular level, has a divergence or genetic distance of at least 25% with respect to HDV of genotypes I-III over the 889-1289 region (R0); (iii) the complete genomes of the isolates or variants dFr-45, -47, -73, -910, -48, or -664; or (iv) a genome with a divergence or genetic distance less than 15% with respect to (iii). Independent claims are also included for: (1) specific fragments of (I); (2) detecting the specified HDV variants by hybridization and/or amplification; (3) detecting and genotyping HDV; (4) recombinant vectors, particularly plasmids, containing (I) or their fragments; (5) cells transformed with (I) or its fragments; (6) translation products (II) encoded by RNA of the specified variants; and (7) proteins encoded by (I), or its fragments, and their peptide fragments. |
