发明名称 |
PEPTIDES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH NITRIC OXIDE |
摘要 |
This invention discloses isolated short peptides comprising the amino acid sequence Cys-Glu-Phe-His (CEFH; SEQ ID NOS: 1 and 15) and analogs thereof as well as compositions comprising CEFH peptides and analogs thereof. The CEFH peptides disclosed herein are effective in mediating the denitration of 3-nitrotyrosines (3-NT) in cellular proteins thereby preventing tissue damage associated with excess nitric oxide (NO) and its reactive species. The CEFH peptides disclosed herein are useful in the treatment of ischemia/reperfusion (I/R) injury and other disorders. |
申请公布号 |
EP2114427(A4) |
申请公布日期 |
2010.11.10 |
申请号 |
EP20070797333 |
申请日期 |
2007.05.03 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
NUDLER, EVGENY, A.;RAFIKOV, RUSLAN, R. |
分类号 |
A61K38/00;A61K38/12;A61P9/10 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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