发明名称 |
PROCESS FOR PRODUCTION OF ARALKYLOXYPYRROLIDINE DERIVATIVE |
摘要 |
<p>The present invention provides a process for producing a 3-aralkyloxypyrrolidine derivative which is important for production of pharmaceutical products and the like. In the present invention, a N-protected-3-hydroxypyrrolidine is converted into a N-protected-3-aralkyloxypyrrolidine by allowing an aralkyl halide to act in the presence of a base and at least one of a metal halide and a phase-transfer catalyst followed by deprotecting a N-protecting group to convert it to a 3-aralkyloxypyrrolidine derivative and subsequently treating the derivative in a solvent containing a polar solvent, thereby obtaining the 3-aralkyloxypyrrolidine derivative as a crystal. According to the present invention, a 3-aralkyloxypyrrolidine derivative of high purity can be produced conveniently and efficiently on an industrial scale.</p> |
申请公布号 |
EP1947083(B1) |
申请公布日期 |
2010.11.10 |
申请号 |
EP20060796649 |
申请日期 |
2006.08.22 |
申请人 |
KANEKA CORPORATION |
发明人 |
TAKEDA, TOSHIHIRO;OHNUKI, MASATOSHI;KISHIMOTO, NARUMI |
分类号 |
C07D207/12 |
主分类号 |
C07D207/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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