发明名称 |
Use of antagonist anti-CD40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection |
摘要 |
<p>Methods of therapy for treating a subject for an autoimmune disease and/or inflammatory disease are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits CD40L-mediated stimulation of CD40-expressing cells, and thus inhibits survival and signaling pathways of human CD40-expressing cells that are mediated by CD40L.</p> |
申请公布号 |
EP2248830(A1) |
申请公布日期 |
2010.11.10 |
申请号 |
EP20100007970 |
申请日期 |
2004.11.04 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
LONG, LI;LUQMAN, MOHAMMAD;YABANNAVAR, ASHA;ZAROR, ISABEL |
分类号 |
C07K16/28;A61K38/20;A61K39/395;A61P29/00;A61P37/06 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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