PIPERAZINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT

摘要

PURPOSE: A pharmaceutical composition containing piperazine derivsative is provided to preventing or treating central nerve diseases. CONSTITUTION: A piperazine derivative is denoted by chemical formula 2. A method for preparing the piperazine comprises: a step of reacting a compound of chemical formula 2 with N-methyl piperazine of chemical formula 3 to prepare a compound of chemical formula 4; a step of reducing the compound of chemical formula 4 to obtain a compound of chemical formula 5; a step of introducing substituent R1 to an amine group of the compound of chemical formula 5; and a step of additionally introducing a substituent to an amine group of the compound of chemical formula 6. A pharmaceutical composition for preventing or treating central nervous system diseases contains the piperazine derivative of chemical formula 1 and pharmaceutically acceptable salt thereof as active ingredients.