发明名称 |
8-METHOXY-9H-ISOTHIAZOLOÄ5,4-BÜCHINOLIN-3,4-DIO E UND VERWANDTE VERBINDUNGEN ALS ANTIINFEKTIVE MITTEL |
摘要 |
<p>The invention provides compound and salts of Formula I and II, disclosed herein, which includes compounds of Formula A and Formula B: Such compounds possess useful antimicrobial activity. The variables R2, R3, R5, R6, R7, and R9 shown in Formula A and B are defined herein. Certain compounds of Formula I and Formula II disclosed herein are potent and/or selective inhibitors of bacterial DNA synthesis and bacterial replication. The invention also provides antimicrobial compositions, including pharmaceutical compositions, containing one or more compounds of Formula I or Formula II and one or more carriers, excipients, or diluents. Such compositions may contain a compound of Formula I or Formula II as the only active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals.</p> |
申请公布号 |
AT482219(T) |
申请公布日期 |
2010.10.15 |
申请号 |
AT20060800428T |
申请日期 |
2006.07.27 |
申请人 |
ACHILLION PHARMACEUTICALS, INC. |
发明人 |
BRADBURY, BARTON JAMES;WILES, JASON ALLAN;WANG, QIUPING;HASHIMOTO, AKIHIRO;LUCIEN, EDLAINE;PAIS, GODWIN CLARENCE GILROY;DESHPANDE, MILIND;PUCCI, MICHAEL JOHN;KIM, HA |
分类号 |
C07D513/04;A61K31/4365;A61P33/00 |
主分类号 |
C07D513/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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