发明名称 |
Modified reoviral therapy |
摘要 |
The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycationic polymer to reduce the clearance of the composition and reduce the immunogenicity of the composition. Yet further, the invention relates to methods of treating a hyperproliferative disease by administering to a patient an effective amount of the modified Reoviridae virus.
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申请公布号 |
US7807179(B2) |
申请公布日期 |
2010.10.05 |
申请号 |
US20070740985 |
申请日期 |
2007.04.27 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
TARRAND JEFFREY;HAN XIANG-YANG |
分类号 |
A61K35/00;A61K35/76;A61K47/48;A61P9/10;A61P19/02;A61P35/00;A61P43/00;C12N5/08;C12N5/22;C12N7/00;C12N15/38;C12N15/46 |
主分类号 |
A61K35/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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