发明名称 |
Variants of hepatitis B virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof |
摘要 |
The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues both in vivo and in vitro. More in particular, reverse transcriptase mutant rt I233V is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti-viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described. Finally, the use of a pharmaceutical composition to cure a subject suffering from a HBV infection, which HBV is resistant to lamuvidine and/or adefovir has been provided, which pharmaceutical composition comprises the nucleoside analogue tenofovir.
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申请公布号 |
US7807437(B2) |
申请公布日期 |
2010.10.05 |
申请号 |
US20060375580 |
申请日期 |
2006.03.15 |
申请人 |
RHEINISHCHE FRIEDRICH-WILHELMS-UNIVERSITAET BONN;UNIVERSITAET ZU KOELN;JUSTUS-LIEBIG-UNIVERSITAET GISSEN |
发明人 |
SCHILDGEN OLIVER;VOGEL MARTIN;MATZ BERTFRIED;ROCKSTROH JUERGEN;KAISER ROLF;DAEUMER MARTIN;HELM MARTIN;WEITNER LUTWIN;SCHEWE CARL KNUD;GERLICH WOLFRAM |
分类号 |
C12N7/00 |
主分类号 |
C12N7/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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