发明名称 |
ANTI MIF ANTIBODIES. |
摘要 |
<p>The present application relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to the C-terminal or the center region of macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and antigen-binding portions thereof further inhibit human MIF biological function. The application also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies and nucleic acid molecules encoding such immunoglobulins. The present application also relates to a method of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies and a method of using these antibodies and compositions for the treatment of MIF-related conditions.</p> |
申请公布号 |
MX2010007406(A) |
申请公布日期 |
2010.10.05 |
申请号 |
MX20100007406 |
申请日期 |
2008.12.30 |
申请人 |
BAXTER INTERNATIONAL INC. |
发明人 |
FRIEDRICH SCHEIFLINGER;RANDOLF KERSCHBAUMER;MANFRED RIEGER;MICHAEL THIELE;C. GEERT MUDDE;JUERGEN MUELLBERG;RENE HOET |
分类号 |
A61K39/395;A61P13/12;A61P35/00;C07K16/24;C12N15/13 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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