PEPTIDE DERIVATIVES INCLUDING HISTIDINE AND USE THEREOF AS ANTI-VIRUS AGENTS OR ANTI-TUMOR AGENTS

摘要

PURPOSE: An antiviral or anticancer drug containing peptide analogue with histidine is provided to control NF-kappaB activity and to prevent or treat NF-kappaB-associated diseases. CONSTITUTION: A peptide analogue with histidine is denoted by formula I(X1-His-X2-X3-His-Gly-X4). In formula I, X does not exist or is at least one amino acid or amino acid having alkyl or an aryl group; X2 is an amino acid having beta-amino acid, gamma-amino acid, D-form amino acid, or N-methyl amino acid; X3 does not exist or is an amino acid with gamma-amino acid, D-form amino acid or N-methyl amino acid; X3 does not exist or is an amino acid having L-form amino acid, D-form amino acid, or N-methyl amino acid; and X4 is an amino acid having L-form amino acid, D-form amino acid or N-methyl amino acid. The peptide analogue is Gly-His-β-Ala-Gln-His-Gly-Val. A composition for treating a NF-kappaB-associated disease contains NF-kappaB activity-regulating material having the peptide analogue and hydrate or salt thereof as an active ingredient.