发明名称 |
Use of pharmaceutical composition containing epidermal growth factor (EGF) for diabetic foot amputation prevention |
摘要 |
The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favoring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrization of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine. Said composition can be used for recalcitrant ulcers which are associated with lesions in the macro and/or microvasculature, patients with inadequate lymphatic and/or venous return and ulcers or other lesions which are difficult to cicatrize and/or heal.
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申请公布号 |
US7799760(B2) |
申请公布日期 |
2010.09.21 |
申请号 |
US20080197001 |
申请日期 |
2008.08.22 |
申请人 |
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA |
发明人 |
BERLANGA ACOSTA JORGE;FERNANDEZ MONTEQUIN JOSE I.;VALDES PEREZ CALIXTO;FRANCO PEREZ NEOBALIS;ROJAS CONSTANTIN INGRID;SANTANA MILIAN HECTOR;CHACON CORVEA LARISSA;GUILLEN NIETO GERARDO E.;HERRERA MARTINEZ LUIS;CANAN-HADEN FRIAS LEONARDO;GERONIMO PEREZ HAYDEE;SOTOLONGO PENA JORGE |
分类号 |
A61K9/08;A61K38/18;A61K9/14;A61K9/19;A61K38/00;A61P9/10;A61P17/02;C07K14/485 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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