| 摘要 |
Disclosed is a pharmaceutical or veterinary ear wash composition comprising: (i) a chelating agent selected from an amino carboxylic acid and salts thereof, (ii) a buffering agent selected from an aminopolyol and salts thereof, and (iii) at least one polymeric biguanide, or a pharmaceutically acceptable salt thereof; wherein the at least one polymeric biguanide is present in the composition in an amount of from 0.02% to 10% w/w, wherein the polymeric biguanide is a compound of formula: X3-[Z-NH-C(=NH)-NH-C(=NH)-NH]n-Z-X4 or a tautomer thereof wherein Z is absent or a divalent bridging group and each Z may be the same or different throughout the polymer; n is at least 3; and X3 and X4 are independently selected from -NH2, -NH-C(=NH)-NH-CN, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclyl and optionally substituted heteroaryl; or a pharmaceutically or veterinarily acceptable salt thereof, wherein an optionally substituted alkyl, cycloalkyl, aryl, heterocyclyl and heteroaryl group is optionally substituted with 1 to 5 groups selected from OH, alkoxy, halo, amino, SH, alkylthio, CO2H, CO2alkyl, CONH2, CONH(alkyl) or CON(alkyl)2. Also disclosed is a method of treating or preventing infections of the external ear of a dog, which comprises the administration of an effective amount of a composition as defined above. |
