Cyclic amide derivatives, and their production and use as antithrombotic agents

摘要

Disclosed is a cyclic amide derivative which inhibits activated blood coagulation factor X (FXa) to exhibit anticoagulant activity and antithrombotic activity. The compound is useful as a drug for treating thrombosis, and is represented by the formula (I): wherein R1 represents a naphthyl which may be substituted with a halogen atom, W represents a bond, a represents 0, 1, or 2, X1 represents a C1-6 alkylene which may be substituted with a hydroxy group, Y1 represents -C(O)-, A represents a piperazine ring or a piperidine ring, and the remaining substituents are as defined in the specification.