发明名称 |
FRAMEWORK RESIDUE SUBSTITUTED HUMANIZED COL-1 ANTIBODIES AND THEIR USE |
摘要 |
The present disclosure provides humanized COL-1 monoclonal antibodies that retain CEA binding affinity, compared to a parent antibody. Also disclosed herein are humanized COL-1 monoclonal antibodies that have reduced immunogenicity, compared to a parent antibody. The disclosed humanized COL-1 antibodies include substitution of framework residues with residues from the corresponding positions of a homologous human sequence. In several embodiments, methods are disclosed for the use of a humanized COL-1 antibody in the detection or treatment of a CEA-expressing tumor or cell in a subject. Also disclosed is a kit including the humanized COL-1 antibodies described herein.
|
申请公布号 |
US2011053264(A1) |
申请公布日期 |
2011.03.03 |
申请号 |
US20100946381 |
申请日期 |
2010.11.15 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE;DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KASHMIRI SYED;KASHMIRI RAFIA MEHDI;SCHLOM JEFFREY;PADLAN EDUARDO A. |
分类号 |
C12N5/10;C07H21/00;C12N15/63 |
主分类号 |
C12N5/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|