| 摘要 |
The present invention relates to 1,4-benzothiazepine derivatives and to a method for preparing thereof and a pharmaceutical composition based thereon, Besides, the present invention relates to limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject, a method of treating and preventing heart failure in a subject, and to preventing cardiac arrhythmia in a subject. Besides, the present invention relates to the use of 1,4-benzothiazepine derivatives for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject, for treating and preventing heart failure in a subject, for preparing a corresponding drug. According to the present invention compounds represent:and also other compounds described in the invention claims. |
