| 发明名称 |
Pyrrolidine and piperidine derivates as NK1 antagonists |
| 摘要 |
A NK 1 antagonist having the formula (I), wherein Ar 1 and Ar 2 are optionally substituted phenyl or heteroaryl, X 1 is an ether, thio or imino linkage, R 4 and R 5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed. |
| 申请公布号 |
EP1882686(B1) |
申请公布日期 |
2011.08.31 |
| 申请号 |
EP20070118674 |
申请日期 |
2002.12.17 |
| 申请人 |
OPKO HEALTH, INC. |
发明人 |
PALIWAL, SUNIL;REICHARD, GREGORY A.;WANG, CHENG;XIAO, DONG;TSUI, HON-CHUNG;SHIH, NENG-YANG;ARREDONDO, JUAN D.;WROBLESKI, MICHELLE LACI;PALANI, ANANDAN |
| 分类号 |
C07D211/60;C07D491/107;A61K31/357;A61K31/40;A61K31/401;A61K31/4015;A61K31/402;A61K31/4025;A61K31/407;A61K31/4166;A61K31/4178;A61K31/4188;A61K31/421;A61K31/435;A61K31/4355;A61K31/437;A61K31/438;A61K31/445;A61K31/454;A61K31/4545;A61K31/499;A61K31/505;A61K31/537;A61K31/5377;A61K31/664;A61K45/00;A61P1/00;A61P1/08;A61P3/04;A61P3/10;A61P9/10;A61P11/00;A61P11/14;A61P13/10;A61P15/00;A61P17/00;A61P25/00;A61P25/04;A61P25/06;A61P25/08;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P25/36;A61P27/02;A61P29/00;A61P31/18;C07D207/14;C07D207/26;C07D207/50;C07D211/28;C07D211/30;C07D211/32;C07D211/34;C07D211/42;C07D211/56;C07D211/72;C07D211/76;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D413/12;C07D471/10;C07D487/10;C07D491/10;C07D498/10;C07D513/10 |
主分类号 |
C07D211/60 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
