发明名称 |
CIRCULAR DUMBBELL DECOY OLIGODEOXYNUCLEOTIDES (CDODN) CONTAINING DNA BINDINGS SITES OF TRANSCRIPTION |
摘要 |
The present invention provides a circular dumbbell oligodeoxynucleotide (CDODN) comprising two loop structures and a stem structure, wherein the stem structure comprises a nucleotide sequence capable of binding the DNA-binding domain of a transcriptional factor. The present invention further provides a pharmaceutical composition comprising said CDODN. The pharmaceutical composition can be used for treating and/or preventing a disease or disorder related to such a transcriptional factor. The present invention also provides a method for treating and/or preventing a disease or disorder related to such a transcriptional factor, comprising administering to the subject a therapeutically effective amount of a CDODN comprising two loop structures and a stem structure, wherein the stem structure comprises a nucleotide sequence capable of binding the DNA-binding domain of the transcriptional factor.
|
申请公布号 |
US2011250261(A1) |
申请公布日期 |
2011.10.13 |
申请号 |
US201113036578 |
申请日期 |
2011.02.28 |
申请人 |
ANGES, MG, INC. |
发明人 |
LEE IN-KYU;MORISHITA RYUICHI |
分类号 |
A61K31/7088;C12N15/11;A61K9/127;A61K31/70;A61K38/00;A61P1/04;A61P3/06;A61P5/14;A61P9/00;A61P9/04;A61P9/10;A61P11/00;A61P13/12;A61P25/00;A61P29/00;A61P35/00;A61P35/04;A61P37/02;A61P43/00;C12N15/09;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|