发明名称 |
METHODS TO IDENTIFY MACROMOLECULE BINDING AND AGGREGATION PRONE REGIONS IN PROTEINS AND USES THEREFOR |
摘要 |
The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.
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申请公布号 |
US2011257104(A1) |
申请公布日期 |
2011.10.20 |
申请号 |
US200913000353 |
申请日期 |
2009.06.19 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;NOVARTIS AG |
发明人 |
CHENNAMSETTY NARESH;HELK BERNHARD;TROUT BERNHARDT;KAYSER VEYSEL;VOYNOV VLADIMIR |
分类号 |
A61K38/16;A61P37/00;C07K14/00;G06F19/00;G06F19/16;G06F19/24 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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