发明名称 |
Compositions Comprising Enzyme-Cleavable Phenol-Modified Opioid Prodrugs and Inhibitors Thereof |
摘要 |
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise a phenol-modified opioid prodrug that provides enzymatically-controlled release of a phenolic opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the phenolic opioid from the phenol-modified opioid prodrug so as to modify enzymatic cleavage of the phenol-modified opioid prodrug.
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申请公布号 |
US2011262360(A1) |
申请公布日期 |
2011.10.27 |
申请号 |
US20100764883 |
申请日期 |
2010.04.21 |
申请人 |
JENKINS THOMAS E;HUSFELD CRAIG O;SEROOGY JULIE D;WRAY JONATHAN W |
发明人 |
JENKINS THOMAS E.;HUSFELD CRAIG O.;SEROOGY JULIE D.;WRAY JONATHAN W. |
分类号 |
A61K49/00;A61K31/485;A61K38/05;A61P25/00;A61P29/00;G01N33/53 |
主分类号 |
A61K49/00 |
代理机构 |
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地址 |
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