Combination vaccine comprising an attenuated bovine viral diarrhea virus and an immunological active component

摘要

Disclosed is a combination vaccine suitable for the treatment and or prophylaxis of cattle against microbiological infections. The disclosed combination vaccine comprises: a) one or more attenuated BVDV, each having at least one mutation in the coding sequence for glycoprotein Erns and at least another mutation in the coding sequence for Npro, wherein said mutation in the coding sequence for glycoprotein Erns leads to inactivation of RNase activity residing in Erns and said mutation in the coding sequence for Npro leads to inactivation of said Npro; and b) one or more immunological active component(s) effective for the treatment and/or prophylaxis of microbiological infection in cattle caused by a bovine pathogen other than BVDV.