| 摘要 |
Disclosed herein are 2-heteroaryl substituted imidazole compounds of formula I(a), I(b), II(a), II(b), III(a), III(b), wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds. Said compounds/compositions are useful in the treatment for reducing the number of circulating lymphocytes in a patient, modulating the amount of S1P in a patient, suppressing immune response in a patient, treating, managing or preventing a disease or disorder, wherein the disease or disorder is ankylosing spondylitis, asthma (e.g. bronchial asthma), atopic dermatitis, Behcet's disease, graft-vs-host disease, Kawasaki syndrome, lupus erythematosus, multiple sclerosis, myasthenia gravis, pollinosis, psoriasis, psoriatic arthritis, rheumatoid arthritis, scleroderma, transplant rejection (e.g. of organ, cell or bone marrow), type 1 diabetes or uveitis.
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