发明名称 |
RECOMBINANT MELUSIN FUSION PROTEIN AS PHARMACOLOGICAL AGENT IN THE TREATMENT OF HEART PATHOLOGIES AND COMPOSITIONS THEREOF |
摘要 |
A recombinant melusin fusion protein having an improved stability and a capability to reach intracellular compartments as compared to recombinant melusin in vivo, wherein said protein comprises i) a human melusin protein having the amino acid sequence as defined in SEQ ID No.:1, or a homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity to SEQ ID No.:1 and having the function of native melusin protein or a human melusin portion derived from SEQ ID No.:1 or homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity of the melusin portion derived from SEQ ID No.:1 and having the function of native melusin protein and ii) a cell penetrating polypeptide. |
申请公布号 |
US2012010386(A1) |
申请公布日期 |
2012.01.12 |
申请号 |
US201113106251 |
申请日期 |
2011.05.12 |
申请人 |
ACCORNERO FEDERICA;BRANCACCIO MARA;TARONE GUIDO;LEMBO GIUSEPPE;CARNEVALE DANIELA;TARGET HEART BIOTEC S.R.L. |
发明人 |
ACCORNERO FEDERICA;BRANCACCIO MARA;TARONE GUIDO;LEMBO GIUSEPPE;CARNEVALE DANIELA |
分类号 |
C07K14/00;C07K14/155;C12N15/63 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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