发明名称 |
PHARMACEUTICAL COMPOSITIONS CONTAINING PEMETREXED HAVING EXTENDED STORAGE STABILITY |
摘要 |
Long term storage stable pemetrexed-containing liquid pharmaceutical compositions are disclosed. The compositions can include pemetrexed or pharmaceutically acceptable salts thereof; an antioxidant selected from lipoic acid, dihydrolipoic acid, methionine and mixtures thereof; a chelating agent selected from lactobionic acid, sodium citrate, tribasic and mixtures thereof; and a pharmaceutically acceptable fluid. The pH of the compositions is in a range of about 8 to about 9.5. The pemetrexed-containing compositions have less than about 5% total impurities, on a normalized peak area response ("PAR") basis as determined by high performance liquid chromatography ("HPLC") at a wavelength of 227nm, after at least about 18 months of storage at a temperature of from about 5 °C to about 25 °C. Methods of preparing the formulation as well as methods of treatment of pemetrexed-susceptible diseases using the same are also disclosed. |
申请公布号 |
WO2012015810(A2) |
申请公布日期 |
2012.02.02 |
申请号 |
WO2011US45341 |
申请日期 |
2011.07.26 |
申请人 |
EAGLE PHARMACEUTICALS, INC.;PALEPU, NAGESH R.;BUXTON, PHILIP CHRISTOPHER |
发明人 |
PALEPU, NAGESH R.;BUXTON, PHILIP CHRISTOPHER |
分类号 |
A61K31/519 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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