发明名称 Migrastatin analog compositions and uses thereof
摘要 In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.
申请公布号 US8202911(B2) 申请公布日期 2012.06.19
申请号 US201113053161 申请日期 2011.03.21
申请人 CORNELL RESEARCH FOUNDATION, INC.;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH 发明人 HUANG XIN-YUN;DANISHEFSKY SAMUEL J.;GAUL CHRISTOPH;NJARDARSON JON T.
分类号 A61K31/12;A61K31/365;A61K31/395;A61K31/435;A61P35/00;C07C49/587;C07D225/02;C07D313/00;C07D405/06;C07D495/04 主分类号 A61K31/12
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