摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to a method for recovery of memory loss caused by a pathology, adverse effects or with time that involves the introduction of an effective amount of (azaheterocyclyl)alkyl amide het(aryl)glycine derivatives of general formula I: wherein: m and n can have values 0, 1, 2 and 3; the sign (#) in what follows means the potential presence of a chiral centre; R represents optionally substituted C5-C10 aryl or 5-6-member hetaryl containing 1-2 heteroatoms specified in nitrogen and sulphur, optionally condensed with a benzene ring with substitutes specified in C1-C8alkyl, C1-C8alkoxy, halogen, OH, CF3, CN, NO2, CF3O, an unsubstituted amino group or a monoC1-6alkyl- or di(C1-6alkyl) substituted amino group, C1-8 alkylsulphanyl, C1-8 alkoxycarbonyl, C1-C6acyl; A1 and A2 independently represents optionally substituted 5-6 member saturated, or aromatic azaheterocyclyl containing 1 to 2 nitrogen atoms in the cycle and optionally condensed with benzene ring; the substitutes in the substituted groups R, A1 and A2 are independently specified in C1-C8alkyl, C1-C8alkoxy, C1-C8 alkylsulphanyl, halogen, OH, CF3, nitro, CN, CF3O, an unsubstituted amino group, mono-C1-4alkyl- or a di(C1-4alkyl) amino group, C1-8 alkoxycarbonyl, C1-C6acyl, or their pharmaceutically acceptable salts or alkyl esters in the form of isolated optical isomers, or their mixtures. The invention refers to the compounds of general formula I, the based pharmaceutical composition and drug. ^ EFFECT: recovery of memory loss caused by a pathology, adverse effects or with time. ^ 16 cl, 24 ex, 1 tbl, 20 dwg |