NOVEL 4-O-METHYLHONOKIOL DERIVATIVES AND COMPOSITION FOR TREATING INFLAMMATORY DISEASE COMPRISING THE SAME AS ACTIVE INGREDIENT

摘要

PURPOSE: A 4-O-methylhonokiol derivative is provided to have excellent anti-inflammation activity by restraining activation of cyclooxigenase-2, thereby capable of being used for medicines for treating various inflammations. CONSTITUTION: A 4-O-methylhonokiol derivative is in chemical formula 1, chemical formula 2, or chemical formula 3. In chemical formula 1, R1 is H, C1-7 alkyl, C2-7 alkenyl, -CO(CH2)nCH3, or -CO-NR5R6, R2 is H or halo, and R3 and R4 is respectively C1-7 alkyl, C2-7 alkenyl, C1-7 hydroxyalkyl, or C3-8 cycloalkyl, C3-8 heterocycloalkyl, or (C3-8 heterocycloalkyl)C1-7 alkyl. In chemical formula 2, R1 is C1-7 alkyl, C2-7 alkenyl, or halo, and R2 is C1-7 alkyl, C2-7 alkenyl, or C1-7 hydroxyalkyl. In chemical formula 3, R1 is C1-7 alkyl, or C2-7 alkenyl, and R2 is C1-7 alkyl, C2-7 alkenyl, C3-8 cycloalkyl, or (C3-8 cycloalkyl)C1-7 alkyl.